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Pharmacovigilance With AI: Signal Detection Beyond the FAERS Spreadsheet

  • 76 minutes
  • 40 slides
What we'll cover
  • 0:00 Why Spreadsheets Plateau Early
  • 8:00 Where AI Actually Fits
  • 18:00 Methods Behind Modern Detection
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What you'll take away

Practical shifts you can apply this week

  • Identify the signal detection tasks where AI adds value beyond spreadsheet-based

    See which PV tasks benefit from AI first, and where manual review still earns its keep.

  • Compare disproportionality, machine learning, and large language model approache

    Choose methods by use case, not buzzwords, with clearer tradeoffs across speed, fit, and validation.

  • Evaluate AI outputs for bias, drift, explainability, and regulatory defensibilit

    Pressure-test model results before they shape signal triage, escalation, or inspection conversations.

  • Design a human-in-the-loop workflow for AI-assisted signal triage and escalation

    Map who reviews what, when humans intervene, and how evidence moves from score to decision.

  • Draft a practical pilot plan with data, metrics, controls, and stakeholder owner

    Leave with a narrow 90-day pilot frame your safety, QA, and data teams can actually run.

Agenda

What we'll cover

  1. 0:00

    Why Spreadsheets Plateau Early

    Where manual review breaks first: volume, fragmentation, reviewer variability, and late prioritisation.

  2. 8:00

    Where AI Actually Fits

    A task map from intake to escalation, with clear boundaries between ranking support and human judgment.

  3. 18:00

    Methods Behind Modern Detection

    Disproportionality, supervised models, NLP, and LLMs, plus where each helps and where it does not.

  4. 30:00

    Signals Need More Than Scores

    Why model outputs need clinical context, data quality checks, and a defensible review path.

  5. 40:00

    Governance That Survives Audit

    Validation, versioning, change control, and documentation that stays legible under inspection.

  6. 47:00

    Failure Modes You Will Meet

    Bad labels, drift, leakage, and automation bias. Less sci-fi, more Tuesday afternoon.

  7. 54:00

    Blueprint For A First Pilot

    Pick one narrow use case, define success metrics, set QA gates, and assign owners for a 90-day test.

  8. 58:00

    Recap And Live Q&A

    Review key decisions, next steps, and attendee questions before you choose your first pilot.

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