USMLE Step 1 Exam Prep

USMLE Step 1 Prep Course (Step 1)

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Everything you need to pass — at the lowest price in the market.

Tutor Mode™ on Every Lesson & Question

A tutor narrates every concept and explains every answer — like having a personal instructor beside you. No extra charge. Competitors sell audio as an add-on.

5,000,000+ SME-Reviewed Questions

Every question reviewed by subject matter experts with high-yield items. Each one comes with a Tutor Mode™ walkthrough — turning static QBanks into personalized review experiences.

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500,000+ Original Illustrations

More original figures, tables, and diagrams than Kaplan, UWorld, and Princeton combined. Created by board-certified PhDs, MDs, and PharmDs.

How MedExPrep compares

Feature-by-feature comparison with every major exam prep platform across all courses.*

Feature	MedExPrep	UWorld	Kaplan	Mometrix	Princeton Review	TrueLearn
Tutor Mode™ on Every Question	✓	✗	✗	✗	✗	✗
Tutor Mode™ on Every Lesson	✓	✗	✗	✗	✗	✗
Audio Lectures (No Extra Cost)	✓	✗	Add-on*	✗	✗	✗
Total Questions (All Courses)	5,000,000+	~3,400/exam*	~2,000/exam*	~500/exam*	~1,500/exam*	~2,000/exam*
Original Illustrations	500,000+	Limited*	Limited*	Minimal*	Limited*	Some*
Free Weekly Webinars	✓	✗	✗	✗	✗	✗
Flashcards Included	✓	✓	Add-on*	Sold separately	✗	✗
Board-Certified Expert Content	✓	✓	✓	Varies*	✓	✓
NCCA / ACPE / ISO Aligned	✓	Varies*	Varies*	✗	Varies*	Varies*
Interview & Career Coaching	✓	✗	✗	✗	✗	✗
Multi-Exam / Multi-Field Coverage	✓	Select exams	Select exams	Many exams*	Select exams	Select exams
Free Preview (No Signup)	✓	✗	✗	Sample only	✗	Limited
Approx. Price Range*	Lowest price 6-month full access	$319 – $719+	$1,999 – $4,000+	$99/mo ($594 for 6 mo)	$1,600 – $7,300+	$149 – $400+

* Comparison based on publicly available information as of 2025. Competitor features, pricing, and content volumes are approximate estimates and may vary by exam, subscription tier, and region. Trademarks belong to their respective owners. MedExPrep totals reflect aggregate content across all courses and exam categories.

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Course Outline — 9 Chapters, 90 Lessons

1 Biochemistry And Genetics 12 lessons ▾

1.1 — Molecular Biology Foundations

1.1.1 DNA Replication And Repair Preview

1.1.2 Transcription And RNA Processing Locked

1.1.3 Translation And Genetic Code Locked

1.2 — Metabolism And Energy Pathways

1.2.1 Glycolysis And Gluconeogenesis Locked

1.2.2 TCA Cycle And Oxidative Phosphorylation Locked

1.2.3 Lipid And Ketone Metabolism Locked

1.3 — Genetic Principles And Disorders

1.3.1 Inheritance Patterns And Pedigrees Locked

1.3.2 Chromosomal And Trinucleotide Disorders Locked

1.3.3 Population Genetics And Screening Locked

1.4 — Nutrition And Molecular Disorders

1.4.1 Vitamin Deficiency Syndromes Locked

1.4.2 Lysosomal And Glycogen Diseases Locked

1.4.3 Porphyrias And Heme Synthesis Locked

2 Cell Biology And Pathology 12 lessons ▾

2.1 — Cell Injury And Death

2.1.1 Cellular Adaptations Locked

2.1.2 Ischemic And Toxic Injury Locked

2.1.3 Apoptosis And Necrosis Patterns Locked

2.2 — Inflammation And Healing

2.2.1 Acute Inflammation Mediators Locked

2.2.2 Chronic Inflammation And Granulomas Locked

2.2.3 Wound Healing And Repair Locked

2.3 — Hemodynamics And Vascular Pathology

2.3.1 Edema And Hyperemia Locked

2.3.2 Thrombosis And Embolism Locked

2.3.3 Shock And Ischemia Syndromes Locked

2.4 — Neoplasia Principles

2.4.1 Oncogenes And Tumor Suppressors Locked

2.4.2 Tumor Progression And Metastasis Locked

2.4.3 Paraneoplastic And Cancer Syndromes Locked

3 Immunology And Microbiology 12 lessons ▾

3.1 — Innate And Adaptive Immunity

3.1.1 Immune Cells And Cytokines Locked

3.1.2 Antibody Structure And Function Locked

3.1.3 Hypersensitivity Reactions Locked

3.2 — Immunodeficiency And Autoimmunity

3.2.1 Primary Immunodeficiency Syndromes Locked

3.2.2 Autoantibodies And Tolerance Loss Locked

3.2.3 Transplant And Tumor Immunology Locked

3.3 — Bacteriology And Antimicrobials

3.3.1 Gram-Positive And Gram-Negative Patterns Locked

3.3.2 Bacterial Toxins And Virulence Locked

3.3.3 Antibacterial Drug Mechanisms Locked

3.4 — Virology Mycology And Parasitology

3.4.1 Viral Replication And Disease Locked

3.4.2 Fungal Pathogens And Mycoses Locked

3.4.3 Parasites And Protozoa Locked

4 Pharmacology Principles 9 lessons ▾

4.1 — Pharmacokinetics And Dynamics

4.1.1 Absorption Distribution Metabolism Excretion Locked

4.1.2 Dose Response Relationships Locked

4.1.3 Adverse Effects And Interactions Locked

4.2 — Autonomic Pharmacology

4.2.1 Cholinergic Receptors And Agonists Locked

4.2.2 Anticholinergics And Cholinesterase Inhibitors Locked

4.2.3 Adrenergic Agonists And Antagonists Locked

4.3 — Autacoids And Toxicology

4.3.1 NSAIDs And Acetaminophen Locked

4.3.2 Opioids And Sedative Toxicity Locked

4.3.3 Sympathomimetic And Antidote Syndromes Locked

5 Systems Foundations 9 lessons ▾

5.1 — Anatomy And Embryology

5.1.1 Embryologic Folding And Germ Layers Locked

5.1.2 Neural Crest And Congenital Syndromes Locked

5.1.3 High-Yield Lesion Localization Locked

5.2 — Physiology And Homeostasis

5.2.1 Membrane Transport And Potentials Locked

5.2.2 Fluid Compartments And Osmolality Locked

5.2.3 Acid Base Interpretation Locked

5.3 — Biostatistics And Ethics

5.3.1 Study Design And Bias Locked

5.3.2 Test Characteristics And Risk Locked

5.3.3 Ethics And Communication Principles Locked

6 Cardiopulmonary Systems 9 lessons ▾

6.1 — Cardiovascular Physiology And Pathology

6.1.1 Cardiac Cycle And Hemodynamics Locked

6.1.2 Ischemic And Valvular Disease Locked

6.1.3 Heart Failure And Arrhythmias Locked

6.2 — Pulmonary Physiology And Disease

6.2.1 Ventilation Perfusion And Gas Exchange Locked

6.2.2 Obstructive And Restrictive Patterns Locked

6.2.3 Pulmonary Infections And Vascular Disease Locked

6.3 — Cardiopulmonary Pharmacology

6.3.1 Antihypertensives And Diuretics Locked

6.3.2 Antianginal And Heart Failure Drugs Locked

6.3.3 Asthma And COPD Drugs Locked

7 Renal Endocrine Reproductive 9 lessons ▾

7.1 — Renal Physiology And Disorders

7.1.1 Glomerular And Tubular Function Locked

7.1.2 Electrolyte And Acid Base Disorders Locked

7.1.3 Nephritic Nephrotic And Tubular Disease Locked

7.2 — Endocrine Physiology And Pathology

7.2.1 Hormone Signaling And Feedback Locked

7.2.2 Pituitary Thyroid And Adrenal Disorders Locked

7.2.3 Diabetes And Calcium Homeostasis Locked

7.3 — Reproductive System And Pregnancy

7.3.1 Gonadal Hormones And Cycles Locked

7.3.2 Reproductive Pathology And Neoplasia Locked

7.3.3 Pregnancy And Teratology Locked

8 Gastrointestinal Musculoskeletal And Skin 9 lessons ▾

8.1 — Gastrointestinal And Hepatobiliary Disease

8.1.1 GI Physiology And Absorption Locked

8.1.2 Inflammatory And Malabsorptive Disorders Locked

8.1.3 Liver Pancreas And Biliary Disease Locked

8.2 — Musculoskeletal And Rheumatologic Disease

8.2.1 Bone Remodeling And Mineralization Locked

8.2.2 Arthritis And Connective Tissue Disorders Locked

8.2.3 Muscle Disease And Pharmacology Locked

8.3 — Dermatology And Connective Tissue

8.3.1 Skin Structure And Lesions Locked

8.3.2 Inflammatory And Blistering Disorders Locked

8.3.3 Pigment And Skin Cancer Disorders Locked

9 Nervous System And Hematology 9 lessons ▾

9.1 — Neuroanatomy And Neuroscience

9.1.1 Neurons Glia And Neurotransmitters Locked

9.1.2 Motor Sensory And Brainstem Pathways Locked

9.1.3 Cerebrovascular And Demyelinating Disease Locked

9.2 — Neurologic Disorders And Pharmacology

9.2.1 Seizure And Antiepileptic Drugs Locked

9.2.2 Movement Disorders And Basal Ganglia Locked

9.2.3 Neuromuscular Disorders And Junctions Locked

9.3 — Hematology And Oncology

9.3.1 Hematopoiesis And Red Cell Indices Locked

9.3.2 Anemias Leukemias And Lymphomas Locked

9.3.3 Coagulation And Transfusion Reactions Locked

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