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Running Multi-Country Trials Without Losing Compliance

  • 78 minutes
  • 41 slides
What we'll cover
  • 0:00 Why Compliance Breaks
  • 8:00 Map The Global Baseline
  • 18:00 Sort Variance From Noise
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What you'll take away

Practical shifts you can apply this week

  • Identify Compliance Fracture Points

    Spot where global-to-local handoffs break down before start-up delays turn into inspection risk.

  • Compare Country-Level Requirements

    See which differences truly affect approvals, safety, data, and oversight, and which are just noise.

  • Design Clear Governance Structure

    Assign ownership for submissions, deviations, safety, and documents so tasks stop floating between teams.

  • Diagnose Early Warning Signals

    Use leading indicators like approval aging and TMF mismatches to catch drift before auditors do.

  • Draft Country Activation Checklist

    Leave with a practical checklist that keeps local adaptation aligned with one global operating model.

Agenda

What we'll cover

  1. 0:00

    Why Compliance Breaks

    Where multi-country trials usually fracture: handovers, fuzzy ownership, and small misses that stack up.

  2. 8:00

    Map The Global Baseline

    Define what cannot drift across countries, from SOPs and TMF standards to exception decision rights.

  3. 18:00

    Sort Variance From Noise

    Compare country rules without losing control of the operating model. Useful differences only.

  4. 29:00

    Build Ownership Before Activation

    Create a workable RACI, activation checklist, escalation path, and one source of truth.

  5. 39:00

    Control Amendments And Safety

    Manage version control, staggered approvals, reconsent, and local reporting triggers without chaos.

  6. 49:00

    Watch The Right Signals

    Track the few indicators that show country-level drift early, while fixes are still boring and cheap.

  7. 56:00

    Apply, Recap, And Q&A

    Work through a pressured scenario, recap the framework, and leave with a 30-day remediation next step.

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