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What Regulators Expect in Clinical Trial Conduct

  • 76 minutes
  • 40 slides
What we'll cover
  • 0:00 Why Conduct Gets Scrutinized
  • 8:00 Who Owns What
  • 18:00 Protocol Compliance In Practice
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What you'll take away

Practical shifts you can apply this week

  • Identify Regulatory Conduct Principles

    Spot how inspectors judge rights, safety, and data integrity when the paperwork looks fine but the system does not.

  • Compare Regulator Expectations Across Functions

    See where oversight, documentation, deviations, and safety management align and where teams often drift apart.

  • Diagnose Common Trial Conduct Failures

    Recognize the repeat patterns that turn small misses into audit findings, warning letters, or awkward follow-up calls.

  • Apply A Risk-Based Approach

    Make clearer calls on CAPA, escalation, and oversight using risk signals that actually lead to action.

  • Draft Practical Inspection Readiness Actions

    Leave with a simple way to turn gaps in active studies into owner-assigned next steps and usable evidence.

Agenda

What we'll cover

  1. 0:00

    Why Conduct Gets Scrutinized

    Start with the regulator's lens: participant protection, credible data, and why tidy files do not guarantee compliant conduct.

  2. 8:00

    Who Owns What

    Sponsor and investigator accountability, vendor oversight, delegation, and what active supervision looks like in practice.

  3. 18:00

    Protocol Compliance In Practice

    How deviations are prevented, detected, classified, and addressed before they become repeat patterns.

  4. 28:00

    Documentation That Holds Up

    ALCOA+, audit trails, source and TMF alignment, and why late reconstruction rarely ages well.

  5. 37:00

    Safety Signals And Escalation

    AE and SAE flow, medical review, escalation paths, and when delays create real regulatory concern.

  6. 46:00

    Risk-Based Oversight And CAPA

    Use KRIs, triggered review, and remediation checks to show that oversight decisions lead somewhere concrete.

  7. 54:00

    Red Flags, Recap, Q&A

    Inspection triggers, credible responses, a 30-day action plan prompt, and live audience questions.

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